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Chronic viral hepatitis

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Chronic viral Hepatitis (CVH) and C at the present stage are characterized mainly lack of disease onset of acute hepatitis, latent and over diagnosed in adolescents and children of primary school age. Clinical variants CVH depend on the etiological factor, and from (reactivity, sex, comorbiditiesI). For CVH-In typical: the presence of moderate inflammatory activity in the liver, small signs of liver and moderate hepatomegaly, the prevalence of the syndrome of chronic non-specific toxicity in the clinical picture. CVH-C is characterized by asymptomatic with persistently normal transaminase levels or moderate their increasediem. Leading to the clinical picture of chronic viral hepatitis is a syndrome of chronic non-specific toxicity. Mechanisms of formation and implementation of toxemia in patients with chronic viral hepatitis, along with common features (mostly strong link with fractions of blood toxins) have differences, which depend mainly on the etiology of the disease.

Elevated levels of toxins in biological fluids of the human body is not always reflected in the clinical manifestations of intoxication syndrome. Therefore, the experts concluded that the existence of whole blood plasma adaptogenic antitoxic systems (AAS). Functional state determines whether AASimplementation of damaging toxins activity on biological structures and the subsequent development of clinical manifestations of intoxication syndrome. AAS plasma significantly affect the toxins in the bloodstream and change the degree of their damaging activity.
The study of any particular endotoxin and determining its concentration in syvoRothko's blood is only a simplification of the problem of endotoxemia. Toxicity - is the result of synergy of all spectrum accumulated in the bloodstream substances. New integrative approach to the characterization of endotoxemia implies not only a statement of the existence of toxemia, but also in-depth study of its parameters and their relationship.

The data analysis toksikometricheskih parameters in children with chronic hepatitis B average show that with some common features toxin (high toxicity of whole blood plasma, strongly associated with toksinonesuschimi blood fractions, no dysfunction of elimination systems of the body, functiontional to the sufficiency of the blood plasma AAS) revealed differences that are subject etiological factor of the disease and the level of activity of the inflammatory process.

The research mechanisms toxin can justify the priorities during the pathogenetic treatment of patients with chronic viral hepatitis.The fact that the majority of patients children have functional adequacy AAS organism in the absence of dysfunction of elimination systems of the body, justifies the possibility of conservative methods of treatment.

attention is given to stimulate macrophage-lymphocyte elimination of toxins,namely the stimulation of phagocytosis, biotransformation processes substances in the liver due to hepatic, membranostabilizatorov. In patients with chronic viral hepatitis C infection plays a leading role mechanism of toxin production, so if you pay attention to the treatment of pharmacological stimulation gepatointestinalnogo way of eliminating toxins, namely stimulation proprocesses and bile secretion, the evacuation of intestinal contents, inhibiting processes gepatointestinalnoy recirculation (enzymes, chelators, Cholagogue). But in both cases, special attention is paid to correcting violations microbiocenosis intestine as one of the leading players in the pathogenesis of chronic viral hepatitisComrade.

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